Teratogenic Potential of Ethylene Thiourea (ETU), A Positive Control in Sprague-Dawley Rats.

Abstract

The teratogenic potential of ethylene thiourea (ETU) was tested in pregnant Sprague-Dawley rats. An aqueous solution of ETU was administered by oral gavage at a dose level of 40 mg/kg on Days 6 through 15 of gestation. Fetuses were delivered by cesarean section on Day 20, weighed, examined externally, and either processed in Bouin's solution for visceral examination or alizarin red stain for skeletal examination. ETU produced teratogenic and embroyotoxic effects in Sprague-Dawley rats. The purpose of this study was to provide historic data demonstrating the Sprague-Dawley rat is sensitive to a known teratogen in the LAIR teratogenicity test system.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1987
Accession Number
ADA189292

Entities

People

  • Don W. Korte Jr.
  • Martha A. Hanes
  • Valerie G. Coppes

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Animal Structures
  • Animals
  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Bone Diseases
  • Crystal Structure
  • Fungi
  • Materials
  • Musculoskeletal Abnormalities
  • Plastic Explosives
  • Quality Control
  • Rats
  • Rodents
  • Skull
  • Toxicology

Fields of Study

  • Agricultural and Food sciences

Readers

  • Toxicology/Environmental Toxicology