Effects of Pharmacologic Intervention on Oxygenation, Lung Water and Protein Leak in the Pseudomonas Ards Porcine Model.
Abstract
The adult respiratory distress syndrome (ARDS) is a pathophysiological pulmonary conditions of multiple etiologies. The syndrome may be initiated by direct pulmonary injury or as the lungs response to a remote or systemic insult. In civilian life the most common causes of ARDS are multiple trauma, aspiration of gastric contents, sepsis and pancreatitis. In combat soldiers, the condition results from blast injuries, direct lung contusion, burn inhalation, inhalation of toxic substances, aspiration, multiple transfusions and as a complication of sepsis. As such, the condition often affects previously fit and healthy patients with a considerable mortality. At the cellular level, the lung injury is due to damage of the alveolar capillary membrane by various circulating elements of the blood, most notably neutrophils. These neutrophils become activated when they come in contact with a soluble or phagocytic stimulus, break down and release many inflammatory mediators. Treatment with cimetidine, diphenhydramine, H2 and H1 blockers, respectively, and ibuprofen, a prostaglandin antagonist, given i.v. at 20 and 120 minutes after pseudomonas infusion, significantly attenuates both the early hypertensive and late permeability phases of the syndrome as measured by hemodynamic parameters, blood gases and slope index and measurement of the extravascular lung water by the indicator dilution technique. Keywords: Blood platelets, Cyclooxygenase, Lipoxygenase, Arachadonic acids, Prostaglandins, Leukotrienes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1987
- Accession Number
- ADA189309
Entities
People
- Harvey J. Sugerman
- James L. Tatum
- Jerry Hirsch
- Karl Byrne
Organizations
- Virginia Commonwealth University School of Medicine