Selected Aspects of Triazolam in Relation to Aviator Performance in Naval Flight Operations,

Abstract

Benzodiazepines often are used for the management of insomnia and anxiety. Operationally, they are likely to be used to phase-shift circadian rhythm. This class of drugs enhances the tendency of gamma aminobutyrate (GABA) to decrease neuronal firing in brain centers associated with sleep. Triazolam, like other benzodiazepines, causes impairment of various central nervous system (CNS) functions, but due to its short half-life, most (but not all) CNS impairments are absent by morning. None-the-less, this review recommends exploring the possible greater value of the newer generation of short-acting benzodiazepines and discourages further consideration of triazolam for operational consideration, because of possible adverse effects on memory and the possible narrow margin of safety. Keywords: Memory(Psychology), Benzodiazepine antagonist, Performance(Human), Short-acting benzodiazepines, Aviation medicine.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1987
Accession Number
ADA189322

Entities

People

  • M. Thornton
  • W. A. Morey

Organizations

  • Naval Aerospace Medical Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amnesia
  • Central Nervous System
  • Clinical Trials
  • Cognition
  • Drug Abuse
  • Drug Therapy
  • Health Services
  • Human Factors Engineering
  • Hypnotics And Sedatives
  • Insomnia
  • Margin Of Safety
  • Medical Personnel
  • Motor Skills
  • Nervous System
  • Pharmacology
  • Psychology
  • Side Effects

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neuroscience
  • Software Engineering