The Blood Volume of the Guinea Pig: Effects of Epinephrine and Isoproterenol upon the Red Cell and Plasma Volumes, Heart Rate, and Mean Arterial Pressure,
Abstract
In the present study, the blood volume of the guinea pig was assessed by direct measures of Hct and dilution samples of autologous red blood cells labeled with sodium chromate. In addition, experimental measures were performed following the administration of the sympathomimetic catecholamine epinephrine to assess the potential influence of splenic mobilization of red cells upon the circulating mass. Doses were selected to elicit maximum contraction of the splenic smooth muscle and discharge of red blood cells. Isoproterenol was administered in identical doses to a separate set of subjects to assess the pharmacological effects of this potent cardiovascular stimulant upon the circulating blood volume. Mean arterial pressure (MAP) and heart rate (HR) were monitored to assess the hemodynamic responses of the system to these agonists. Likewise, measures were performed upon splenectomized individuals for comparison of the systemic effects of the catecholamines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1987
- Accession Number
- ADA189403
Entities
People
- Gregory A. Millnamow
Organizations
- Letterman Army Hospital