Studies to Control Endemic Typhoid Fever in Chile

Abstract

A multi-faceted program of applied research has been undertaken in collaboration with the Ministry of Health of Chile intended to lead to control of endemic typhoid fever in Santiago, Chile. These studies include: 1) Maintenance of prospective field trials evaluating the efficacy of Ty21a live oral typhoid vaccine given in various formulations and immunization schedules. 2) The first evaluations of Ty21a vaccine in infants and pre-school children. 3) Development of a new enzyme-linked immunosorbent assay (ELISA) to measure Vi antibodies and its use as a serologic screening test to identify chronic typhoid carriers. 4) Evaluation of a new oral antibiotic regimen to eradicate the chronic typhoid carrier state without resort to surgery. Keywords: Salmonellosis; Vaccine; Epidemiology; Enteric infections.

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Document Details

Document Type
Technical Report
Publication Date
Mar 30, 1987
Accession Number
ADA189504

Entities

People

  • Catterine Ferreccio
  • Myron M. Levine

Organizations

  • University of Maryland, Baltimore

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Blood
  • Chemistry
  • Escherichia Coli
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Side Effects
  • Vaccines
  • Vegetables

Readers

  • Infectious Disease/Epidemiology

Technology Areas

  • Biotechnology