Teratogenic Potential of 4-Nitrophenyl Methyl Phenyl Phosphinate (MPP) in Rats.
Abstract
The teratogenic potential of 4 nitrophenyl methyl phenyl phosphinate (MPP) was tested in pregnant Sprague Dawley rats. MPP was administered by oral gavage on Days 6 through 15 of gestation. Dose levels tested were 0,0.12, 1.25, and 3.12 mg/kg/day. The vehicle contained 21.5 Tween 80, 18.5% absolute ethanol, 37.5% 50 mM citrate buffer, and 22.5% distilled water. Fetuses were delivered by cesarean section on Day 20 and weighed, examined externally, and either processed Bouin's solution for visceral examination or alizarin red stain for skeletal examination. MPP did not produce dose-related teratogenic or embryotoxic effects in Sprague Dawley rats. Keywords: Developmental Toxicology, Teratology, 4 Nitrophenyl methyl phenyl phosphinate, Rats, Phosphinates, Methyl radicals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1987
- Accession Number
- ADA189622
Entities
People
- Don W. Korte Jr.
- Martha A. Hanes
- Valerie G. Coppes
Organizations
- Letterman Army Hospital