The Effect of an Experimental Missile Wound to the Brain on Brain Electrolytes, Regional Cerebral Blood Flow and Blood Brain Barrier Permeability.

Abstract

We have developed an experimental gun to inflict a precise transcranial missile wound to the brain of a cat. The missile is a 30 mg steel sphere which optimally deposits 1.3 Joules of energy in the right cerebral hemisphere. After wounding, a breakdown of the blood-brain barrier occurs and alterations of the brain water sodium and potassium are seen. Immediately after missile impact arterial hypertension and bradycardia ensue. Respiratory abnormalities also occur. Wounds of 1.8 Joules or greater cause immediate respiratory arrest and sometimes cause brain stem hemorrhages. Keywords: Brain damage, Wounds and Injuries, Response(Biology).

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Document Details

Document Type
Technical Report
Publication Date
Sep 15, 1984
Accession Number
ADA190250

Entities

People

  • Michael E. Carey

Organizations

  • LSU Health Sciences Center New Orleans

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Blood
  • Blood Flow
  • Blood-Brain Barrier
  • Brain
  • Brain Injuries
  • Brain Stem
  • Cardiac Arrhythmias
  • Cardiovascular Physiological Phenomena
  • Classification
  • Determinants (Mathematics)
  • Hemorrhage
  • Laboratory Animals
  • Physiological Effects
  • Physiology
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Strategic Security Studies
  • Trauma or Military Medicine