Three Proteins Made by Glial Cells of the Goldfish (C. auratus) Optic Nerve Undergo Increased Synthesis Following Trauma to the Optic Nerve.
Abstract
Glial cells have been shown to increase the levels of synthesis of selected proteins in response to damage inflicted upon their associated axons. These proteins may be instrumental in mediating axonal repair. In this study proteins synthesized by the glial cells of the goldfish optic nerve were examined using tissue incubation, polyacrylamide gel electrophoresis, and gel fluorography. Ten days after monocular nerve crush or monocular enucleation, three glial proteins were found to have increased levels of synthesis relative to controls. These enhanced glial proteins, or EGPs, were detectably increased relative to controls at 4.5 hr after nerve trauma, and returned to control levels of synthesis by 6 months post-crush. Keywords: Nerve regeneration, Proteins, Glia, Goldfish, Optic nerve, Growth substances.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1987
- Accession Number
- ADA190302
Entities
People
- Harry Zqick
- John Freeman
- Michael A. Deaton
- Susan E. Bock
Organizations
- Letterman Army Hospital