Genotoxic Potential of Reactive-Polymer in the CHO HGPRT (Chinese Hamster Ovary Hypoxanthine-Quanine Phosphoribosyl Transferase) Forward Mutation Assay and CHO Sister Chromatid Exchange Assay

Abstract

Reactive-polymer and its component parts were tested for their abilities to induce forward mutations in the CHO HGPRT Forward Mutation Assay and to damage DNA as measured by the CHO Sister Chromatid Exchange Assay. All materials were tested over dose ranges to include cytotoxic and noncytotoxic doses. Neither reactive-polymer nor its components induced a significant rise in the mutant frequency in the CHO HGPRT assay or in the frequency of sister chromatid exchanges. Theses data suggest a low genotoxic potential for reactive- polymer. Keywords: Mutagenicity, Genetic toxicology, HGPRT, Sister chromatid exchange, Chinese hamster ovary cells, Reactive-polymer.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1987
Accession Number
ADA190516

Entities

People

  • Don W. Korte Jr.
  • John W. Harbell
  • Lillie D. Witcher

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Biological Sciences
  • Biomedical Research
  • California
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chromosome Structures
  • Classification
  • Genetics
  • Materials
  • Military Research
  • Pharmacology
  • Toxicity
  • Toxicology

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech