Development of a Calcifiable Matrix for Bone Formation.
Abstract
As a contractual, development-synthetic effort, this project had two goals. The first was the delivery to the USAIDR of approximately 13 grams of synthetic peptide for in vivo study of calcifiability, ossification, biocompatibility and wound repair issues. The second goal was the characterization of the peptide in matrix form with respect to its in vitro calcification, stress-strain properties, biocompatibility and chemotaxis potential. This project was developmental in nature an objective was the elaboration of an off the shelf matrix for bone formation with the approach being based on a polypentapeptide. This polymer, when cross-linked into an insoluble matrix, calcified massively on exposure to normal human serum dialyzates. Keywords: Peptide synthesis, Sequential polypeptides, Polymerization methods, Y-irradiation cross-linking, Cross-linked polynonapentapeptide, Chemotaxis, Wound cover, Osteogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1987
- Accession Number
- ADA190612
Entities
People
- Dan W. Urry
Organizations
- University of Alabama at Birmingham