Development of Microcomputer Methods for Analysis and Simulation of Clinical Pharmacokinetic Data Relevant to New Drug Development.
Abstract
The research proposed under this contract is a feasibility study in the development of applications of new microcomputer graphics technology to the continuing development of comprehensive programs for analysis, interpretation, and simulation of pharmacokinetic data, dose-response kinetic data, and other data relevant to new drug development, for use with the Tektronix 4052 Microcomputer Graphics System. The combination of such modern analytical and illustrative methods in clinical pharmacology, based on new high-speed microcomputers and associated graphics, are thought to greatly reduce both cost and time involved in the overall process of clinical evaluation of new drugs in the U.S. Army Drug Development Program. The work performed includes the following: Continuing developments of the programs for the analysis and simulation of non-linear kinetic data. Development of a translation program for the conversion of various sets of pharmacokinetic parameters into a uniform set. Keywords: Clinical pharmacokinetics, Dose-response relations, Pharmacokinetic simulation, Non-Parametric statistics, Mefloquine, Microcomputer graphics, Pharmacology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 29, 1985
- Accession Number
- ADA190902
Entities
People
- Robert Wagoner
- Thorir D. Bjornsson
Organizations
- Duke University