Mutagenic Potential of Nitroguanidine in the Mouse Lymphoma Forward Mutation Assay

Abstract

The mutagenic potential of nitroguanidine was assessed in the mouse lymphoma thymidine kinase forward mutation assay both with and without metabolic activation by rat liver. In the initial range-finding assay, cells were exposed to test compound concentrations ranging from 4 milligram/milliliter to 0.01 milligram/milliliter. The confirmatory assay employed doses from 4 milligram/ milliliter to 1 milligram/milliliter. Nitroguanidine did not induce a statistically significant increase in the mutant frequency in either of the two assays. These results indicate that nitroguanidine was not mutagenic under the conditions of this study. Keywords: Mutagenicity, Genetic toxicology, Mouse lymphoma assay, Mutagenesis, In vitro, Nitroguanidine; teratology; Toxic tolerances.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1987
Accession Number
ADA190926

Entities

People

  • Don W. Korte Jr.
  • John W. Harbell

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Sciences
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Frequency
  • Materials
  • Military Research
  • Mutations
  • Nitroguanidine
  • Propellants
  • Range Finding
  • Thymidines
  • Toxicology
  • Triple Base Propellants

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation
  • Biotechnology - Cancer Biotech