Potential Benefits and Hazards of Humoral Immune Reactions against HTLV-III.
Abstract
Gp120 binding to CD4 requires beta-glycanase sensitive carbohydrate chains to retain binding ability. A 28Kd fragment of Gp120 has been identified with complete retention of CD4 binding capacity. Human monocytes can be readily infected with HIV. In the absence of anti-HIV antibodies, phagocytic or non-phagocytic monocytes are equally sensitive. Anti-HIV antibodies at certain high dilutions may enhance HIV proliferation in human monocytes although exact conditions causing such enhancement are not yet defined. Certain human HIV-seropositive individuals produce high titered antibodies which display molecular mimicry with CD4 and bind to Gp120. Such antibodies may tentatively be linked to good prognosis. Keywords: Human immunodeficiency virus, Immunosuppression, Immunity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 10, 1987
- Accession Number
- ADA191002
Entities
People
- Hans Wigzell
- Kenneth Nilsson
- Magnus Gidlund