Mechanisms of Rapid Nonspecific Resistance Induced by Immunomodulators: Delineation Using Selective Depletion of Cells. .

Abstract

The effects of a wide variety of endogenous and exogenous immunomodulators were applied in mouse models permitting in vivo and in vitro analysis of effector mechanisms in rapid non-specific resistance. Major attention was given to models in which circulating monocytes and NK cells were depleted in short-term and long-term administration of the bone-seeking isotope, strontium. Techniques for the use of free and liposome-encapsulated cytotoxins were studied in vitro and in vivo. Toxins included ricin, ricin A-chain and dichloromethylene diphosphonate (DMDP). Keywords: Macrophages, Monocytes, Listeria, Immunotherapy, Interferons, Immunomodulators, Bone marrow depletion, Liposomes, Prostaglandins, Ricin, Ricin A-chain, Dichloromethylene diphosphonate.

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Document Details

Document Type
Technical Report
Publication Date
Jan 28, 1988
Accession Number
ADA191430

Entities

People

  • Alvin Volkman
  • Page S. Morahan

Tags

DTIC Thesaurus Topics

  • Allergy And Immunology
  • Anti-Infective Agents
  • Blood
  • Bone Marrow
  • Cells
  • Chemistry
  • Cytotoxins
  • Infection
  • Leukocytes
  • Listeria Monocytogenes
  • Macrophages
  • Microbiology
  • Military Research
  • Nuclear Magnetic Resonance
  • Phagocytes
  • Proteins
  • Toxicity

Readers

  • Immunology
  • Molecular and Cellular Biochemistry

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech