Pathogenesis and Prevention of Acute Renal Failure.

Abstract

Several in vitro studies on the isolated perfused kidney (IPK) and renal tubules freshly isolated from the rate were performed to evaluate the mechanism of oxygen deprivation injury and protection. Emopamil, a calcium channel blocker, prevented both warm and cold ischemia in the IPK. Cold perfusion alone is also of benefit and can be enhanced by verapamil. Atrial peptide III (the atrial natriuretic factor; ANF) exerts protection to the IPK from renal ischemia injury as well as in the whole animal. Using NMR, the protection appears to involve preservation of adenine nucleotides and prevention of intracellular acidosis. Furthermore, fructose diphosphate is also protective possibly by providing glycolytic intermediates. The tubule studies were characterized by technical improvements in preparative and incubation techniques and development of methods to ensure anoxic injury and its sequelae. Keywords: Acute renal failures, Hypoxia, Nuclear magnetic resonance.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1987
Accession Number
ADA191561

Entities

People

  • Robert W. Schrier

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Albumins
  • Amino Acids
  • Arteries
  • Blood
  • Cells
  • Classification
  • Dermatologic Agents
  • Glucose
  • Hypermetabolism
  • Laboratory Animals
  • Magnetic Resonance
  • Metabolic Diseases
  • Metabolism
  • Nuclear Magnetic Resonance
  • Pathogenesis
  • Resonance
  • Security

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry