Intraerythrocytic Killing of Malaria Parasites.

Abstract

The purpose of these studies is to determine the role of activated macrophages in immunity to the blood stages of malaria. This is being accomplished by comparing the activity of macrophages during lethal and non-lethal malaria infections and in malaria-resistant and non-resistant mice. The results indicate that in non-lethal P. yoelii infection of mice, macrophage activity, as determined by H2O2 release, gamma-interferon production and lymphoproliferation, is high early in infection, declines during the time of peak parasitemia and recovers as the infection is cleared. Although some macrophage functions are enhanced during the early phase of lethal P. yoelli infection, this enhancement is not sustained. Recombinant gamma-interferon, infected into mice, had a protective effect in susceptible mice with lethal infections but not in non-lethal infections. Keywords: Erythrocytes; Pathology.

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Document Details

Document Type
Technical Report
Publication Date
Sep 30, 1987
Accession Number
ADA191983

Entities

People

  • Hannah L. Shear

Organizations

  • NYU Langone Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biological Factors
  • Blood
  • Cells
  • Chemistry
  • Classification
  • Immunity
  • Infection
  • Lymphatic System
  • Macrophages
  • Monocytes
  • New York
  • Parasites
  • Parasitic Diseases
  • Production
  • Proteins
  • Security

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).
  • Parasitology and Pharmacology of Malaria.