A Study of the Nephrotoxicity and Metabolism of Tetralin and Indan in Fischer 344 Rats.

Abstract

A group of male and female 344 rats were dosed with tetralin over a 14 day period. Histopathology of the kidneys revealed significant damage to the renal tubules of the dosed male rats compared to control male rats dosed with water. Both groups of female rats dosed with tetralin or water showed no kidney damage. The urine metabolites of tetralin identified from both male and female rats included 1-tetralol, 2-tetralol, 2-hydroxy-1-tetralone, 4-hydroxy-1-tetralone, 1,2-tetralindiol and 1,4-tetralindiol. No metabolites of tetralin were isolated from the kidney extracts of dosed animals. Keywords: Hydrocarbon nephrotoxicity, Tetralin metabolism.

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Document Details

Document Type
Technical Report
Publication Date
Feb 08, 1988
Accession Number
ADA192118

Entities

People

  • M. P. Serve'

Organizations

  • Wright State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Alkanes
  • Blood
  • Body Weight
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Cyclic Hydrocarbons
  • Hydrocarbon Fuels
  • Kidney Diseases
  • Kidneys
  • Materials Science
  • Metabolism
  • Organic Chemistry
  • Sodium Compounds

Readers

  • Petroleum Engineering
  • Toxicology/Environmental Toxicology