Interactions of Lipid Vesicles with Blood Proteins and Platelets.
Abstract
We have examined the interactions of hemoglobin containing liposomes and of liposomes composed of polymerizable phospholipids with blood cells and proteins. All types of liposomes studied bound a variety of serum proteins with IgG being the most abundant component in each case. Polymerized methacrylate liposomes specifically bound a 53 kilodalton protein not bound by other liposome types. None of the liposomes tested provoked platelet aggregation; however, unpolymerized methacrylate liposomes markedly inhibited ADP induced platelet aggregation. Most liposomes tested did not affect clotting of plasma; however, polymerized methacrylate liposomes bound clotting factor V and thus inhibited clotting.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1987
- Accession Number
- ADA192245
Entities
People
- Rudolph L. Juliano
Organizations
- University of Texas Health Science Center at Houston