Fourteen-Day Subchronic Oral Toxicity Study of 4-Nitrophenyl Monochloromethyl (Phenyl) Phosphinate in Male Rats.

Abstract

The 14-day subchronic oral toxicity of 4-nitrophenyl monochloromethyl (phenyl) phosphinate (MCP) was evaluated in male rats. MCP was administered by gavage at dose levels of 0,12.5, 25, 50 and 100 mg/kg/day for 14 days. At necropsy blood samples were obtained for hematological and serum clinical analyses. A complete histological examination was performed on all animals. In addition, plasma, red blood cell, and brain acetylcholinesterase and butyrylcholinesterase activities were determined. Although MCP was lethal to one rat in both the 50 and 100 mg/kg dose groups, no definitive pattern of clinical chemical, hematological or histopathological alterations was found. This suggests that the deaths observed could be due to a transient toxic response associated with cholinesterase inhibition.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1988
Accession Number
ADA192251

Entities

People

  • Carlyn M. Lewis
  • Craig W. White
  • John C. Turnier
  • Paul P. Waring
  • Thomas P. Kellner

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Analytical Chemistry
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Data Storage Systems
  • Hemorrhage
  • Lymph Nodes
  • Lymphatic System
  • Medical Personnel
  • Nose
  • Plastic Explosives
  • Statistical Analysis
  • Tissues

Readers

  • Toxicology/Environmental Toxicology