Determination of Drug Pharmacokinetics and Metabolic Profile. Volume 1
Abstract
The pharmacokinetics and metabolism of halofantrine, WR 171,669, have been studied in beagle dogs after oral doses of 5 to 100 mg/kg of the carbon-14 labelled drug. The routes and rates of excretion and plasma and blood concentrations of the drug and its metabolites were measured. A similar investigation was carried out with WR 178,460, the N-desbutyl derivative of WR 171,669, administered as a single oral dose of 21 mg/kg to dogs. Rates and routes of excretion and plasma and blood concentrations of WR 158,122 and its metabolites have been investigated in rhesus monkeys after administration of 10 mg/kg oral doses to animals with cannulated bile ducts. Metabolites were quantified after chromatographic separation and information on their structure obtained by mass spectrometry of isolated samples. Keywords: Pyridostigmine, Cholinesterase inhibitors, Labeled substances, Halofantrine hydrochloride.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1988
- Accession Number
- ADA192427
Entities
People
- David R. Hawkins