Plasma Volume Expansion in Rats: Effects on Thermoregulation and Exercise,
Abstract
Administration of polyethlene glycol (PEG, intraperitoneal, 3ml, 30% solution) to adult, male rats (300g) resulted in an approximate 20% increment in plasma volume (PV) 24 h after PEG injection. When these animals were exercised (9.14 m/min, level treadmill) in a warm 30 C, 30-40% rh) environment, their mean endurance was increased from 67.9 min (saline-treated controls, CONT) to 93.6 min. Total water loss was increased from 12.2g (CONT) to 17.2 g (PEG). Atropine administration (ATR, 200 ug/kg, tail vein) significantly reduced both the endurance and the salivary water loss of CONT and PEG-treated rats while increasing the heating rate of both groups. PEG treatment reduced the hematocrit and circulating protein levels both prior and subsequent to exercise in the warm environment. Clinical chemical indices of heat/exercise injury were generally unaffected by pharmacological intervention while clinical chemical responses to exercise were related to the endurance time of each group. We concluded that expansion of PV by PEG provided significant beneficial effects on performance and thermoregulation during exercise in a warm environment. Keywords: Polyethylene glycol, Atropine, Salivation, Physical performance, Indices of heat injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1988
- Accession Number
- ADA192656
Entities
People
- C. Matthew
- M. Bosselaers
- R. Hubbard
- R. P. Francesconi
Organizations
- United States Army Research Institute of Environmental Medicine