Influence of Altitude and Caffeine during Rest and Exercise on Plasma Levels of Proenkephalin Peptide F.
Abstract
The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300m) and caffeine ingestion (4mg.KgBW-1). Nine healthy male subjects performed exercise tests to exhaustion at sea level, during an acute altitude exposure (1 hr. hypobaric chamber) and after a chronic (17 day sojourn) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p<0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise an in the post-exercise period at sea level. Conversely, caffeine ingestion at altitude resulted in significant reductions in the post-exercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other ECPs) and epinephrine release in response to these types of physiological stresses. Keywords: Endogenous opioid peptides, Altitude acclimatization, Lactate, Cardiovascular, Caffeine, Endurance exercise.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1988
- Accession Number
- ADA192659
Entities
People
- Charles S. Fulco
- Jeff P. Bonner
- Paul B. Bock
- Scott E. Gordon
- William J. Kraemer
Organizations
- United States Army Research Institute of Environmental Medicine