Acute Oral Toxicity of Nitroguanidine in Male and Female Rats
Abstract
The acute oral toxicity of nitroguanidine was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose limit test method. Test results indicated that the median lethal dose was greater than 5000 mg/kg body weight in both male and female rats. The predominant clinical signs associated with nitroguanidine administration were urinary excretion of a whitish precipitate (nitroguanidine) in the first 24 hours followed by excretion of a reddish urine for up to a week. Nitroguanidine also affected the gastrointestinal tract as it produced diarrhea with perianal staining and irritation of the mucosa of the stomach and small intestine. Excessive secretion from the harderian gland was also observed as a red nasal discharge and staining around the nose and mouth. These results place nitroguanidine in the practically nontoxic category based on the toxicity classification system of Hodge and Sterner. Keywords: Mammalian toxicology, Munitions, Propellants, Acute toxicity, Explosives.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1988
- Accession Number
- ADA192694
Entities
People
- Conrad R. Wheeler
- Don W. Korte Jr.
- Larry D. Brown
Organizations
- Letterman Army Hospital