Dermal Sensitization Potential of a Schistosome Topical Antipenetrant Lotion in Guinea Pigs.

Abstract

A schistosome topical antipenetrant lotion, containing 1% niclosamide, was tested for its potential to produce dermal sensitization. The Guinea Pig Maximization Test was used to evaluate dermal sensitization potential. Grade II (mild) dermal sensitization to the lotion was obtained in this study. These results suggest that there is probable risk that the schistosome topical antipenetrant lotion will induce contact sensitivity in humans.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1988
Accession Number
ADA192696

Entities

People

  • Dean K. Magnuson
  • Denzil F. Frost
  • Don W. Korte Jr.

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Animals
  • Bandages
  • Biological Sciences
  • Escherichia Coli
  • Filter Paper
  • Gastroenteritis
  • Health Services
  • Hydrocarbons
  • Materials
  • Medical Personnel
  • Military Personnel
  • Military Research
  • Polyethylene Glycols
  • Polyethylenes
  • Propenes
  • Quality Control

Fields of Study

  • Biology

Readers

  • Marine Ecological Systems Migration
  • Toxicology/Environmental Toxicology