A Paradoxical Role for Eicosanoids: Radioprotectants and Radiosensitizers

Abstract

Understanding the radiobiology of eicosanoids is complicated by their ability to act as mediators of damage and recovery and as radioprotective agents. Changes in the tissue concentrations of eicosanoids following irradiation are dependent on several factors, including the type of eicosanoid, time postirradiation, radiation dose, and other contributing mediators and enzyme changes in the surrounding microenvironment. Many of these same prostaglandins and the leukotrienes have been shown to be radioprotective when given before irradiation.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1987
Accession Number
ADA192775

Entities

People

  • Thomas L. Walden Jr.

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Cardiovascular System
  • Cells
  • Chemistry
  • Gamma Rays
  • Ionizing Radiation
  • Lipids
  • Metabolism
  • Neoplasms
  • Nucleotides
  • Radiation
  • Radiation Injuries
  • Radiation Protection
  • Radioprotective Agents
  • Rodents
  • Tissues

Fields of Study

  • Physics

Readers

  • Immunology and Pathology
  • Nuclear and Radiation Engineering.