The Effect of Acute Renal Failure on Muscle Protein Turnover in the Rat and Implications for Therapy.
Abstract
Acute renal failure (ARF) often accompanies and complicates the management of combat casualties suffering from extensive trauma and prolonged hypotension. Despite replacement of blood, fluids and electrolytes, expert surgical care, antibiotics and hemodialysis, the overall mortality has remained high (50-60%). The Underlying cause of death is not renal failure now that dialysis is available, but the associated hypercatabolic state in which wound healing is delayed, increased susceptability to infection is present and nutritional inanition results. Negative muscle protein balance is a major feature in this metabolic setting and there is suggestive evidence that protein catabolism and mortality in acute renal failure may be modified by therapy directed towards reducing muscle protein degradation. This study was designed: 1. To explore, in a model of ARF in the rat, the balance of protein synthesis and degradation in a series of representative muscles: the diaphragm, heart, soleus and extensor digitorum longus. 2. To devise a therapeutic regimen to reduce muscle protein catabolism and enhance muscle protein synthesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1984
- Accession Number
- ADA192847
Entities
People
- Arthur S. Kunin
Organizations
- University of Vermont