Differentiation of a Human Monocytic Cell Line Associated with Increased Production of Rift Valley Fever Virus by Infected Cells
Abstract
Rift Valley fever (RVF) virus is a cause of significant human and animal disease in many parts of Africa. In some cases, it causes a hemorrhagic fever, which is frequently fatal. Prior studies have shown that RVF virus productively infects peritoneal macrophages from susceptible rat strains. The U937 human monocytic cell line was used to determine the effect of monocytic cell differentiation on the degree of viral production by cell cultures infected with RVF virus. Differentiation of U937 cells to more mature monocytic cells by phorbol ester resulted in production of 10 times more infectious virions in comparison with undifferentiated cells. These studies imply that monocytic cell differentiation increases permissiveness for RVF virus production.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1987
- Accession Number
- ADA192902
Entities
People
- Clarence J. Peters
- John C. Morrill
- Richard M. Lewis
- Thomas M. Cosgriff
Organizations
- United States Army Medical Research Institute of Infectious Diseases