Pharmacologic Studies on the In Vitro Bronchodilating Vasoactive Actions of Oligo-PGB.

Abstract

We have determined that oligo-prostaglandin B (oligo-PGB) relaxes airways of guinea pigs when studied in vitro. In this study we used both high molecular weight mixture (HMW) and oligo-PGB forms of the compound. We also investigated whether or not the relaxation is dependent upon the concentration of oligo-PGB, the contractile substance used to enhance tone, the integrity of epithelial cells layer and the release of cyclooxygenase metabolites. We further analysed the effect of oligo-PGB on 'acute' (protocol IV) and 'chronic' (protocol V) preparations in regard to the immediate hypersensitivity phenomenon. In the chronic preparation, the tissue was incubated in the presence of oligo-PGB for 18 or 24 hours.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1986
Accession Number
ADA192994

Entities

People

  • James A. Will

Organizations

  • University of Wisconsin–Madison

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Contracts
  • Epithelial Cells
  • Epithelium
  • Hypersensitivity
  • Incubation
  • Metabolites
  • Molecular Weight
  • Prostaglandin
  • Rodents
  • Smooth Muscle
  • Statistical Analysis
  • Tissues
  • Wisconsin

Fields of Study

  • Medicine

Readers

  • Allergy and Immunology.
  • Cardiovascular Physiology