Primary Screening of Potential Radioprotective Agents.
Abstract
This report deals with primary screening of potential radiation protective agents. The drugs to be tested were provided by the U.S. Army Medical Research and Development Command, Fort Detrick, Maryland. The compounds were tested in toxicity screens to determine the maximum tolerated dose (MTD) effects. Limited available drug amounts precluded more refined testing. The second screen involved Cobalt-60 gamma radiation. The agents to be tested were injected intraperitoneally into CDI female Swiss mice, thirty minutes prior to irradiation with either 9.0 or 9.5 Gy. The latter value was found to be the radiation LD100(30) for this mouse strain. Survival was measured and the degree of protection was determined. Dose modification factors were determined on a limited number of agents as directed by the COR. Keywords: Radiobiology, Radiation protective agents, Low LET radiation, Protectors, Mice, Drug development, Drug effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1987
- Accession Number
- ADA193139
Entities
People
- Curtis P. Sigdestad
Organizations
- University of Louisville