Physiological Mechanisms of Acute Intestinal Radiation Death
Abstract
The overall objective was to clarify the role of fluid and electrolyte loss, bile-duct ligation, radiation-damaged intestinal mucosa, bacterial toxemia and their interrelationships on radiation-induced gastrointestinal death. Using specific pathogen-free CD-1 male rats, this study found that endogenous enteric bacteria did not play a significant role in pure intestinal radiation death. Bile acids, per se, were shown to play little role in intestinal radiation death but that the inability of the denuded mucosa to absorb fluid and electrolytes, thereby producing hypovolemic shock was the major mechanism. Keywords: Neutron exposure; Gamma ray exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1986
- Accession Number
- ADA193629
Entities
People
- Joseph P. Geraci
- Kenneth L. Jackson
Organizations
- University of Washington