Protein Structure and Function: Design and Synthesis of Peptide Recognition Sequences.
Abstract
The long-range goal of this research is to elucidate the molecular mechanism of protein-protein recognition and binding. The immediate goal is to undertake the synthesis and chemical modification of model peptide ligands, to characterize the structure of these peptides through NMR spectroscopy and x-ray crystallography, and to test their function in in vitro and in vivo assay systems. We also propose to identify and characterize the primary and secondary structure of the cell membrane receptor(s) of the ligands. Models of cell membrane receptor-peptide ligand binding will be constructed from structural studies of the purified receptor, NMR analysis of ligand binding to the receptor, and from monoclonal antibody surrogates reacting with the peptide active site.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 18, 1988
- Accession Number
- ADA193746
Entities
People
- Albert S. Mildvan
- Cecil H. Robinson
- Mario L. Amzel
- Thomas J. August
Organizations
- Johns Hopkins University