Macromolecular Instabilities and Dynamical Coding in Brain Enzymes, Polypeptide Ligands, Polypeptide and Cholinergic Receptors, and Sodium and Cholinergic Channel Proteins

Abstract

This is a summary of the program of work beginning in 1983 and addressing the issue of reversible to non-reversible transitions in brain relevant allosteric proteins studied and modeled as far-from-equilibrium dynamical systems. Stimulated by the issues not involving co-valent bonding in the aging phenomenon of cholinergic neurotoxins, a polypeptide-psychotropic drug strategy for buying time vis-a-vis manomolecular stability is suggested. A new, low dimensional ligand-receptor coding scheme was developed in collaboration with Roger Guillimin. New work on a simular scheme involving a channel protein design is now on-going in collaboration with Maurice Montal.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1988
Accession Number
ADA194018

Entities

People

  • Arnold J. Mandell

Organizations

  • University of California, San Diego

Tags

Communities of Interest

  • Energy and Power Technologies
  • Weapons Technologies

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Antidepressants
  • Chemistry
  • Computer Programming
  • Computers
  • Differential Equations
  • Dynamics
  • Equations
  • Families (Human)
  • Instability
  • Membrane Proteins
  • Nonlinear Dynamics
  • Phase Transformations
  • Power Spectra
  • Psychotropic Drugs
  • Spectra

Fields of Study

  • Chemistry

Readers

  • Adaptive Control and Estimation with Uncertainty in Dynamic Systems.
  • Molecular and Cellular Biochemistry
  • Research Science/Academic Research