Low Doses of Atropine Sulfate Impair Retention of a Well-Learned Spatial Task.
Abstract
Retention of a well-learned spatial task was assessed in rats 10 minutes prior to, and 10, 20, 30, 40 and 50 minutes after treatment with 3, 10 or 30 mg/kg, iv, atropine sulfate or the equivalent volume of saline, iv. There was a variable dose effect for escape latency and choice accuracy measures of spatial retention. A relatively large dose of atropine sulfate (30 mg/kg, iv) significantly impaired choice accuracy and escape latency compared with the control group. Moreover, impairment in choice accuracy was observed with the control group. Moreover, impairment in choice accuracy was observed with smaller doses of atropine sulfate (3, 10 mg/kg, iv) than have previously been shown to disrupt spatial retention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1988
- Accession Number
- ADA194065
Entities
People
- D. I. Welch
- L. Gallego
- T. M. Bauch
Organizations
- United States Army Research Institute of Environmental Medicine