Study of the Effects of Drugs upon the Cardiovascular and Respiratory Systems.
Abstract
A comparison was made of a variety of cardiovascular and pulmonary effects of WR-6026.2HCl and primaquine diphosphate in anesthetized dogs utilizing dose rates which were either only minimally effective in producing changes or those producing marked effects just short of death. Cardiopulmonary actions of these two drugs differed. In the cardiovascular system, the predominant effect of primaquine was an increase in pulmonary vascular resistance. A modest depression of cardiac contractility was noted for all dose- rates, but this was evident only at the end of the experimental period. The major effects of WR-6026-2HCl were a weakening of ventricular contractility and a construction of the pulmonary vasculature. These effects were significant at the middle and high doses, but either did not occur or were unimportant at the low dose. There was some short-lived increase in P-R interval and Q-T interval by the high dose, but no cardiac arrhythmias. Respiratory rate was transiently raised during high dose-rate infusion of primaquine. Compliance appeared variably affected by the different dose-rates of primaquine. On the respiratory system, WR-6026 produced immediate elevations of respiratory rate and minute volume at all dose-rates tested. WR-6026 also produced a prominent depression in airways resistance at the higher doses. The most dangerous effect of WR-6026 is progressive depression of cardiac contractility to the point of ineffective cardiac pumping. In contrast, the potentially lethal action of primaquine is upon cardiac rhythm.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1985
- Accession Number
- ADA194390
Entities
People
- Clinton B. Nash
- Robert W. Caldwell
Organizations
- University of Tennessee