New Synthetic Approaches to TAT
Abstract
In continuation of our current research project we are trying to obtain new synthetic approaches to the TAT molecule along the following three pathways (cf. previous Interim Reports): (a) ring synthetic methods from small molecules; (b) selective bridge removal in DAPT; (c) template catalyzed cyclomerization of methyleneimines. A fourth pathway ('ureas as starting materials') mentioned firstly in the 6th Interim Report, namely to perform simple alpha-ureidoalkylation (cf. H. Petersen, Synthesis 1973, 243) to obtain dioxotetrazocanes, or to start with N,N'-dimethylurea and formaldehyde (according Kadowaki, Bull.Chem.Soc. Japan 11, 248 (1936)), has been further developed to a novel and independent approach to the tetrazocane molecule.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 16, 1988
- Accession Number
- ADA194588
Entities
People
- Heinrich Wamhoff
Organizations
- University of Bonn