Development of Vaccines to Prevent Wound Infections Due to Anaerobic Bacteria.

Abstract

Progress on the two major objectives of this contract has been made. The first objective was to bottle and provide safety testing on a Bacteroides fragilis capsular polysaccharide preparation. The antigen was prepared in our laboratory and bottled by the Massachusetts State Public Health Laboratory. The material passed all safety and pyrogenicity studies required by the Food and Drug Administration. The second objective was to study the lymphokine produced by immunization with the polysaccharide. We have shown that a lysate of splenic T cells from animals immunized with the capsular polysaccharide, transfers protection to recipients. The protective material appears to be a lymphokine which is a protein, of small molecular weight. This factor is antigen specific for the immunizing antigen. Keywords: Human hybrido lymphokines; Anaerobic organisms; Laboratory animals.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1984
Accession Number
ADA194644

Entities

People

  • Dennis L Kasper

Organizations

  • Brigham and Women's Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anaerobic Bacteria
  • Animals
  • Bacteria
  • Bacteroidaceae
  • Blood Cells
  • Cell Line
  • Cells
  • Food
  • Health
  • Health Services
  • Laboratory Animals
  • Lymphocytes
  • Materials
  • Molecular Weight
  • Public Health
  • Rodents
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Environmental Engineering
  • Immunology
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology