An Evaluation of Two Configurations of Tricalcium Phosphate for Treating Craniotomies,

Abstract

Biodegradable beta-tricalcium phosphate disks (TCP) of 2 configurations were inserted into 15mm diameter craniotomy wounds and non-treated control sites were evaluated in 60 rabbits. There were no adverse tissue reactions and no apparent difference in the clinical appearance of the 12 and 24 week implanted disks. By 36 weeks and continuing to 48 weeks, the omnidirectional TCP (OTCP) implants were degrading more rapidly than the unidirectional TCP (UTCP) implants, with degradation progressing centripetally and replacement by woven bone and maturing lamellar bone. Host implant interface of both TCP configurations was a bone bond without interposed soft tissue. TCP disks may be clinically useful for craniotomy repair. Key words: Bone regeneration, tricalcium phosphate disks, calvaria; osteogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1986
Accession Number
ADA194783

Entities

People

  • Craig Hassler
  • James W. Mizgala
  • Jeffrey O. Hollinger
  • John P. Schmitz

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Beta Testing
  • Biocompatible Materials
  • Bone And Bones
  • Bone Marrow
  • Bone Regeneration
  • Bones
  • Cells
  • Diameters
  • Materials
  • Osteogenesis
  • Peptide Growth Factors
  • Physical Properties
  • Skull
  • Soft Tissues
  • Tissues
  • Wounds And Injuries
  • X Rays

Readers

  • Computer Science/Computer Engineering/Data Science/Digital Signal Processing.
  • Trauma Surgery or Emergency Medicine.