Safety Testing of Dengue-2 and Dengue-4 Viruses for Use in Human Challenge Experiments

Abstract

Safety testing of attenuated dengue virus vaccines and challenge viruses: Dengue 2 (PR-159) Parent, non-attenuated; Dengue 4 (H-241) Parent, non- attenuated; and Dengue 3 (H53489) Production seed and control fluids was conducted. For each of the viruses, the following substances were tested separately for sterility and presence of adventitious agents: Freeze dried virus; Virus fluids, unclarified; Control fluids, day 7, unclarified; Control fluids, day 14, unclarified; and Pre-inoculation fluids. In addition, the identify of each virus was determined by breakthrough neutralization tests. All tests were concluded satisfactorily. No adventitious agents were detected and the identity of the viruses was confirmed.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1988
Accession Number
ADA195177

Entities

People

  • Nyven J. Marchette

Organizations

  • University of HawaiĘ»i System

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biomedical Research
  • Carbon Dioxide
  • Classification
  • Contracts
  • Dengue
  • Laboratory Animals
  • Plastic Explosives
  • Procurement
  • Rodents
  • Schools
  • Security
  • Shipping Containers
  • Tropical Medicine
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Materials Science
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology