Drug Resistance in Malaria: Investigation of Mechanisms and Patterns of Drug Resistance and Cross Resistance in Malaria.

Abstract

This contract had five technical objectives: (1) identification of binding sites of drugs (mefloquine, etc.) in erythrocytes and/or parasites, (2) investigation of binding of drugs (mefloquine in particular) in malaria strains resistant and susceptible to other drugs (chloroquine in particular), (3) investigation of the mechanism of action of drugs (mefloquine in particular) and the effect on metabolism of erythrocytes and parasites, (4) correlation of drug resistance and accumulation of drugs by infected erythrocytes to allow predictions of cross resistance, and (5) development of a method to predict cross resistance based on response of isolated malaria parasites to drug-receptor complexes. Keywords: Antimalarials; Drug resistance, Drug receptors, Ferriprotoporphyrin IX, Phospholipids, Chloroquine, Mefloquine, Quinine, Sickle cells, Hemoglobinopathies.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 19, 1987
Accession Number
ADA195325

Entities

People

  • Coy D. Fitch

Organizations

  • Saint Louis University

Tags

DTIC Thesaurus Topics

  • Animals
  • Biochemistry
  • Biological Sciences
  • Cell Membrane
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Drug Receptors
  • Drug Resistance
  • Erythrocytes
  • Infectious Diseases
  • Malaria
  • Pigments
  • Rocket Oxidizers
  • Sickle Cells
  • United States

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Parasitology and Pharmacology of Malaria.