Assessment of Neurological Effects of Drugs on Oculomotor and Visual Function in the Primate.

Abstract

A number of cholinergic agents are deemed useful as prophylactics or antidotes to organophosphate poisoning yet have their own toxic effects. Dosages of these agents which are known to not grossly disrupt behavior may nonetheless degrade performance of sophisticated tasks required of the personnel of a modern mechanized army. The contract uses an animal model (primate) to assess the effects of cholinergic drugs on the performance of visual search and tracking tasks which mimic skills generally used in the field. The eye movements of cynomolgous monkeys (Macaca fascicularis) were recorded with the magnetic search coil technique while they searched for camouflaged targets or tracked moving targets. A preliminary analysis was completed of the effects of atropine on performance of the Visual Search and Target Tracking tests as well as on the effects on the Visual Search test of atropine/pralidoxime and pyridostigmine. (AW)

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Document Details

Document Type
Technical Report
Publication Date
Dec 15, 1983
Accession Number
ADA195557

Entities

People

  • E. G. Keating

Organizations

  • State University of New York

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Atropine
  • Biomedical Research
  • Contracts
  • Correlation Analysis
  • Cross Correlation
  • Data Science
  • Eye
  • Eye Diseases
  • Eye Movements
  • Information Science
  • Laboratory Animals
  • Macaca Fascicularis
  • Medical Personnel
  • Moving Targets
  • Poisoning
  • Target Tracking

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology
  • Vision Science/Vision Psychology/Cognitive Neuroscience.