Assessment of Neurological Effects of Drugs on Oculomotor and Visual Function in the Primate.

Abstract

Monkeys were given cholinergic drugs in doses considered to provide protection against organophosphate poisoning. Their eye movements were recorded while they carried out visual search and target tracking tasks. In general these agents had subtle effects. At the worst, monkeys remained capable of carrying out moderately good search and tracking performance. Pyridostigmine (7 mg/K) was the most benign, having no observable effect. Pralidoxime impaired behavior only at the highest dose (16 mg/K). Similarly, atropine and physostigmine degraded performance clearly and consistently only at the highest dose tested (.25 mg/K and .075 mg/K respectively). Degraded search and tracking was generally attributable to impaired oculomotor competence, rather than to altered visual, cognitive, or motivational status. Keywords: Antidotes. (AW)

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Document Details

Document Type
Technical Report
Publication Date
Oct 10, 1984
Accession Number
ADA195558

Entities

People

  • E. G. Keating

Organizations

  • State University of New York

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abnormalities
  • Animals
  • Atropine
  • Central Nervous System
  • Computers
  • Eye Movements
  • Laboratory Animals
  • Magnetic Fields
  • Medical Personnel
  • Military Personnel
  • Nervous System
  • Plastic Explosives
  • Poisoning
  • Reaction Time
  • Target Tracking
  • Targets
  • Two Dimensional

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Neurotoxicology
  • Neurotrauma and Rehabilitation Medicine.