Oxime-Induced Reactivation and Efficacy against Lethality in Phosphinate-Intoxicated Guinea Pigs.

Abstract

These experiments were designed to determine whether oximes can induce reactivation of inhibited blood AChE in animals given organophosphinates (phosphinates). The questions addressed were (1) whether oximes can reactivate phosphinate-inhibited guinea pig AChE in vivo and in vitro, (2) which oxime and concentration is most effective in restoring AChE activity, (3) nature of the profiles of AChE inhibition by phosphinates in vivo, and (4) evaluation of the effectiveness of atropine + oximes against phosphinate-induced lethality. (KT)

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1988
Accession Number
ADA195619

Entities

People

  • Claire N. Lieske
  • Dana R. Anderson
  • Jose A. Mireles
  • Larrel W. Harris

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Classification
  • Inhibition
  • Inhibitors
  • Lethality
  • Medical Personnel
  • Military Research
  • Nerve Agents
  • Rodents
  • Security
  • Standards
  • Test And Evaluation
  • Vehicles

Fields of Study

  • Biology
  • Chemistry

Readers

  • Neurotoxicology
  • Systems Analysis and Design