Study of Erythrocyte Lipid Peroxidation and Deformability in Individuals with Sickle cell Trait (HBC).

Abstract

Tread mill exercise causes an increase in the activity of SOD, GSHPx and 6-PGA dehydrogenase without any change in the activity of catalase and G-6-P dehydrogenase in SCT RBC. However, it did not affect the activity of any of the peroxide scavengers, but increased the activity of both NADPH generating enzymes in normal. Exercise did not have any significant effect on lipid peroxidation potential of either normal or SCT RBC. However, it caused an increase in the calcium content in SCT which was associated with an increase in the activity of sodium, potassium - calcium -ATPases of RBC membranes. Furthermore, exercise caused an increase in the amount of light membranes in SCT RBC. Keywords: Sickle cell trait; Physical stress; Lipid peroxidation; Deformability; Exercise(Physiology). (KT)

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Document Details

Document Type
Technical Report
Publication Date
Feb 14, 1988
Accession Number
ADA195704

Entities

People

  • Salil K. Das

Organizations

  • Meharry Medical College

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Blood
  • Blood Cells
  • Blood Gases
  • Cell Count
  • Cell Membrane
  • Cells
  • Classification
  • Death
  • Erythrocytes
  • Heart Rate
  • Hematologic Diseases
  • Peroxides
  • Physical Properties
  • Security
  • Sickle Cells

Readers

  • Exercise and Sports Science.
  • Molecular and Cellular Biochemistry