Biological Evaluation of Radioprotective Drugs.
Abstract
The cellular and molecular mechanisms of radioprotection by aminothiols are being investigated through the use of both cultured mammalian (CHO) cells and a whole-animal model, specific-pathogen free mice. For each of these systems, detailed structure-activity relationships are being compiled which relate the effects of the different drugs on various endpoints for the survival of clonogenic cells and on the induction and repair of several types of DNA lesions in these same cells. The data obtained with cultured cells are used as a means of understanding or predicting the effects on tissues. A major finding is that tissue oxygenation appears to play an important role in determining both the extent and mechanism of protection, and that understanding the interrelationships between oxygen, aminothiols and radiation sensitivity will be a crucial step in our ability to utilize such drugs effectively. Keywords: Radioprotection; Aminothiols; Cultured cells; Jejunum; Bone marrow; Mouse; Cell survival; Animal survival; DNA Damage; Radioprotective agents. (KT)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1988
- Accession Number
- ADA195710
Entities
People
- David Murry
Organizations
- The University of Texas MD Anderson Cancer Center