Mechanisms of Chemical Modulation and Toxicity of the Immune System.
Abstract
The results of experiments performed during this reporting period assess possible mechanisms involved in immunoregulation by 1,1-Dimethylhydrazine (UDMH). Treatment of mice with UDMH suppresses activity and production of interleukin-1 (L1) by partially blocking (IL1) receptor expression. Interleukin-2 (IL2) activity and production was also suppressed by UDMH, although the basal level of IL2 receptor was not affected. UDMH may partially reverse the immunosuppressive effects of Corynebacterium parvum in mice by interfacing with PGE2 production, but not hydrogen peroxide. Preliminary results show UDMH may affect murine splenic T-lymphocyte populations defined by helper/inducer (L3T4) and suppressor/cytotoxic (LYT-2) monoclonal antibodies. Antigen presenting B-cells and macrophage also show variable la antigen expression upon exposure to UDMH. These experiments are just getting underway, but early results show UDMH increases intracellular Ca (++) within a few seconds of its addition to murine splenocytes in the resting state (without mitogen). The interaction of UDMH of intracellular (Ca(++) levels could help define mechanisms of UDMH-induced immunomodulation. Keywords: Toxicity. (AW)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 15, 1988
- Accession Number
- ADA195715
Entities
People
- Melinda J. Tarr
- Richard G. Olsen
Organizations
- Ohio State University