Role of Afferent Nervous Stimulation in Hemorrhagic Shock,
Abstract
Pigs anesthetized with chloralose and urethane were used to determine the effects of sciatic nerve stimulation on the physiologic responses to rapid hemorrhage. Compared to sham-operated controls, a majority of the stimulated animals showed significant elevations in blood pressure and cardiac output. There were no effects of stimulation on right atrial, pulmonary artery or pulmonary capillary wedge pressure. Although plasma epinephrine and norepinephrine levels were greatly elevated by hemorrhage, there was too much variability to ascertain responses to stimulation. Sectioning the nerve proximal (but not distal) to the stimulating electrodes abolished all hemodynamic effects. A minority of animals showed hypotensive responses to sciatic stimulation. These responses may have been due to a selective activation of a subpopulation of afferents. We conclude that hemorrhage accompanied by afferent, stimulation results in a hemodynamic status different than exists following blood loss alone. (kt)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 07, 1988
- Accession Number
- ADA195940
Entities
People
- John O'benar
Organizations
- Letterman Army Hospital