Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organo Phosphate Action.
Abstract
In year 02 we have finished one objective of demonstrating that the release of ACh is within the target area, the cerebral cortex, by establishing that the effect is blocked by local administration of atropine, and that the quantity of ACh released is small. Moreover, we have, by chemical and immunocytochemical methods, established that the source of ACh is likely to be small cholinergic nerves adjacent to cerebral vessels and/or ACh synthesized in capillary endothelium. Keywords: Acetylcholine, Atropine sulfate, Cerebral cortex, Cerebral blood flow, Choline acetyltransferase, Cortical microvessels, Electron microscopy, Fastigial nucleus, GABA, HPLC, Immunocytochemistry, Neurotransmitter release, Vasodilation, Rats, Cholinergic nerves. (AW)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1986
- Accession Number
- ADA195948
Entities
People
- Costantino Iadecola
- Donald J. Reis
- Stephen Arneric
Organizations
- Weill Cornell Medicine