Molecular Biology of Proteins Acting in Immune Response Mechanisms
Abstract
This research is directed at a further understanding of the role of specific membrane glycoproteins in the cellular response to the environment, with particular reference to proteins acting in immune response mechanisms. We have focused on characterizing newly identified membrane glycoproteins whose biochemical properties provide evidence that they function in cell recognition, receptor, or response mechanisms. The major advance has been the identification and characterization of two glycoproteins that function specifically as principal components of the lysosomal membrane. The understanding of these membrane glycoproteins opens wholly new directions for studies of the mechanisms of lysosomal function in antigen presentation, processes involved in specific intraorganellar membrane flow, and the biogenesis of lysosomes. The studies have also encompassed the Ly-24 (Pgp-1) lymphocyte cell surface alloantigen, whose function appears to involve an association with plasma membrane proteoglycans and cell adhesion. Keywords: Molecular biology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1988
- Accession Number
- ADA196455
Entities
People
- J. T. August
Organizations
- Johns Hopkins University