Fourteen-Day Subchronic Oral Toxicity Study of Nitroguanidine in Rats
Abstract
The 14-day subchronic oral toxicity of nitroguanidine was evaluated in male and female rats. Nitroguanidine was administered in the diet at dose levels of 0, 100, 316, and 1000 mg/kg/day for 14 days. The addition of nitroguanidine to the diet did not have an effect on food consumption, but there was a significant dose-response increase in water consumption. Clinical signs attributable to the test compound were not observed during the study. At necropsy, blood samples were taken for hematological and serum clinical analyses. Serum potassium and calcium values were decreased in the treated dose groups. Microscopic examination of tissues from the control and 1000-mg/kg/day/ dose group animals revealed no lesions attributable to the administration of nitroguanidine. These findings indicate that nitroguanidine is nontoxic in rats when administered at doses as high as 1000 mg/kg/day for 14 days. The findings of serum electrolyte decreases coupled with increased water consumption suggest that nitroguanidine, which is excreted unchanged in the rat's urine, may be acting as an osmotic diuretic. Keywords: Subchronic oral toxicity; Nitroguanidine; Toxicology; Rat; Response(Biology); Physiological effects; Toxic tolerances; Triple base propellants; Ammunition; Hazardous wastes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1988
- Accession Number
- ADA196666
Entities
People
- Carolyn M. Lewis
- Don W. Korte Jr.
- Earl W. Morgan
- Larry D. Brown
- Robert R. Dahlgren
Organizations
- Letterman Army Hospital