A Preliminary Study of the Osteogenic Potential of a Biodegradable Alloplastic-Osteoinductive Alloimplant

Abstract

A biodegradable copolymer of polylactide:polyglycolide (PLA:PGA) was combined with allogeneic decalcified freeze-dried bone (DFDB) and implanted into 15 mm diameter defects in the calvaria of 26 New Zealand White rabbits. Similar defects were created in the calvaria of another 26 rabbits. These animals served as controls and did not receive copolymer implants. Upon sacrifice, both the implants and the controls were evaluated clinically, radiographically, and histomorphometrically using a Zeiss Image Analysis System. Both controls and implants were evaluated in groups at 4, 8, 12, 16, 20, and 24 weeks. When compared with the control defects, the copolymer:DFDB implants displayed a significantly greater volume of trabecular bone. Three of the 15 mm diameter defects displayed evidence of complete osseous bridging at 8 weeks. No adverse host tissue responses were observed histologically in any of the implant specimens. Keywords: Bone regeneration, Bone fracture repair, Surgical implants.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1987
Accession Number
ADA196766

Entities

People

  • Jeffrey O. Hollinger
  • John P. Schmitz

Organizations

  • Walter Reed Army Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Bone And Bones
  • Bone Fractures
  • Bones
  • Cells
  • Composite Materials
  • Connective Tissue
  • Copolymers
  • Diameters
  • Laboratory Animals
  • Orthopedic Surgical Procedures
  • Osteoblasts
  • Osteogenesis
  • Particles
  • Polymers
  • Surgery
  • Teeth

Readers

  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Microelectronics